There's one big problem with that....there's no such thing as an '80 240SX.
But I'll assume you mean '89-'93 240SX's. I guess anything's possible with the right amount of money. There should be plenty of room in the engine bay. You'd likely need to do some fabrication....like engine mounts, etc. I don't know about hood/cross member clearance issues...I can't foresee any--350's are fairly compact.
You know...now that I think about it, I bet your friend meant '80 280ZX (or was is 260 then?). That is a much more common swap. I've never heard of a 350 in a 240SX.
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