I did a drive from San Fran to SD and I didn't have a problem either of the times I've done it other than morons trying to race. I prefer doing the drive at night since theres not so many cars on the road and I like driving through the fog. The heat also won't be a problem if you don't have a/c while driving at night. Just don't get caught up and drive like the many bad drivers in SD and you'll be fine.
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