I think your wording may be incorrect.. detonation usually means the car is running lean. From your description, it sounds like it is running overly rich, causing it to miss and backfire out the exhaust.
You may have a leaky or bad injector. Also check the condition and replace all your spark plugs (setting to proper gap). If you have one bad injector, the plug on that cylinder will be black / much darker than the rest, or wet. You can also test the resistance of the injector to ensure its within spec.
If all spark plugs seem the same condition, replace all and see if it persists or if it helps.. it may be an ignition issue then.
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