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That's where the centerfire distinction should come into effect.
Rimfire rounds are all relatively ineffective on people (.22WMR and .17HMR are both fairly deadly in the vitals) and are hilariously ineffective against even the most mundane of body armor. Rimfire, by nature of construction, is less reliable (in terms of failures to fire) than centerfire and also by nature of construction doesn't feed as well unless it's a revolver or tube magazine.
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